Emeritus since 1988. Main interests have been the action mechanism of local anaesthetics and the mechanism behind the active transport of sodium and potassium across the cell membrane. During the local anaesthetic research I more or less by accident discovered that there is a Na + K activated ATP hydrolyzing enzyme in the crab nerve membrane which has the characteristics necessary for a sodium pump. It was later substantiated that it was the sodium-potassium pump, which is in nearly all mammalian cell membranes.
At present my interest is computer simulation of the active transport reaction.
References to the local anaesthetic investigations see Skou, J. C., J. Pharmacy and Pharmacol. 12: 204, l961.
References to investigations on the Na,K-Pump:
Skou, J. C., The effect of some cations on an adenosine triphosphatase from peripheral nerves Biochim. Biophys. Acta, 23: 394-401, l957.
Skou, J. C. and Esmann, M. The Na,K-ATPase. J of Bioenergetics and Biomembranes, Vol. 2, no. 3 pp. 249-261, 1992
Skou, J. C., The identification of the sodium pump, Bioscience Rep. 18: 155-169, l998.
Front Page Home Department
Research Na,K-ATPase E-type-ATPase
Forside Hjem
Institut Forskning Na,K-ATPase
E-type-ATPase
Teaching Staff ScS
TAS Calendar Search
Undervisning Personale VIP TAP
Kalender Søgning